Another perfect (and sad) moment: Deadpool
Yes, there are thousands of moments. THOUSANDS of this dude to choose from. So here we go...
From Wolverine Origins 24
Wade totally looks like Freddy Krueger there.
This, I think, is a top moment. Not my fave (I had to add it at the bottom just to spice things up), but I think it's very definitive of the character. And I know, people are hacking on Daniel Way, but hear me out: Wade's never been out for revenge. Sure, he wanted to kill Killebrew, but I don't think it was because of revenge. More of a sense of justice. But seriously, if there's anyone who should be out for revenge -- it's him! He had cancer and was tortured in hopes of curing that cancer. Yet, he's not really out to get anybody. He is that tragic clown that uses humour to deflect his insecurities and even though he jokes about being an X-Man, I think deep down inside he really really wants to be included. Most of the people he knows/cares about have betrayed him (even Siryn, IMO, during Joe Kelly's run, when she walks away from him after telling him a few issues earlier she'd be there for him no matter what, yadda yadda yadda)
Anyways, now for *my* fave/perfect Wade moment:
The face! The face!
And my friend, irish_spectre cropped it so now you can have your own fun!