The cover to Daredevil #500, by Marko Djurdjevic and news about the creative team.
Okay, let's see: Typhoid Mary, Echo, Milla Donovan, Black Widow, Karen Page, Bullseye & Elektra, Mister Fear, Gladiator, Dakota North, Ma Murdock (haven't seen her in a long while), Matt's head, Gaudy Classic Daredevil, Young Matt, Current Daredevil, Foggy Nelson, Battlin' Jack Murdock, the Owl, Black Tarantula, Bullseye, Lady Bullseye, Tombstone, the Kingpin, Iron Fist, Luke Cage, the Hand.
And Andy Diggle will be taking over with #501, according to Da Q on his MySpace post. His credits include the current run on Thunderbolts and DC's The Losers and Green Arrow: Year One, so he strikes me as having the right credentials for the book (which, as Quesada noted, has an extremely impressive creator history since the 80s).
Brubaker's depature with #500 (#120, v.2 numbering) will make for a 39-issue run (a few of those more than regular size), a very good length these days; the opening arc (#82-86) and everything since Rucka's co-written period (#105-present) have been excellent; the intervening stuff a bit more middling ("The Devil Takes A Ride" I found pretty dull, though the finale with Vanessa Fisk was a great ending for the character; the yearlong Mister Fear stuff went on longer than it needed to, though it reads a lot better collected). The current "Return of the King" promises to be a great finale (a preview for the first issue of that here by the way).