Oh yes, HI YO SILVER ran for more than thirty issues, beginning in 1952. Judging from the covers, Silver faced hazards of nature (like blizzards and rockslides), duels with rival stallions, fights with cougars and bison. He had a recurring nemesis, an Indian brave who wanted to capture him.
Dell titles like these usually had solid art and storytelling, although they weren't shocking or extreme enough to draw much interest today.