Oh. Well, OK, if it's already been established in recent continuity, that's different - although it TOTALLY contradicts earlier stories where his cancer goes away for a while due to his healing factor and everything's hunky-dory. Anyway, I still don't see how regenerative processes can 'go out of control'. They're REgenerative processes, not generative processes - their purpose is to fix what's wrong in the body, not just grow stuff. If it were the latter, then that would make sense in terms of the exploding (I guess), but NOT in terms of Deadpool himself - a generative process wouldn't just heal his wounds, it would make him bigger and lumpier every time he got injured, because it GENERATES; it grows bigger. Another gutshot? Whoops, better grow a big ol' mound of flesh to cover it over. At this point in his career, he'd look like a misshapen ball of lumpy growths, about a thousand times worse than he is now; there'd be precious little human about him. A REgenerative process, on the other hand, simply slaps on some putty, as it were, and heals the wound. I don't see how something like that could make you explode minus cancer. Anyway. Like I said, if it's been established, it's been established. But it's dumb, nonetheless.