Way too much analysis of Twinkie ad follows
I've never tasted Twinkies, since they don't sell them in the UK where I live, but from what I've heard they don't taste that good. I think someone likened them to cardboard once, this makes the exalted idolised godlike status of them in the adverts pretty hilarious and I think the writers fully knew this. You can tell they had fun writing these.
Some of these Twinkie ads tell better stories in one page than many of the multi part epics of today. Even with the standard Twinkie as deus ex machina ending that is rarely deviated from.
I like to believe that the redhead in the last panel is Mary Jane. Also, is that the bridge that Gwen Stacy got thrown off to her death?
The sugar frosted poignancy of the piece is indeed liable to give indegestion. Or something.