First off, I'd love to play one of the Blue Mountain State guys against anyone else from the show or even possibly an OC. I can fill you in on any character if you are interested. They are Craig Shilo, Alex Moran, and Thad from my icons.
Secondly, I'd love either a high school or college line with one of my football players against just about anyone else. A cheerleader, the dean's daughter, a teacher's wife... etc etc.