Considering how recognizable the character is (I mean, "Lois Lane" rings a bell with millions who have never read a comic), I can see her own title being launched. She'd be an ambitious freelance journalist contributing to the DAILY PLANET but also selling stories to cable news and posting on her own blog. The natural approach would be to have her going after corruption in the government (local and federal), military and corporations.
The new angle I would suggest would be to have her a well-known figure who is very unpopular with half the country because she keeps showing them things they don't want to think about. Lois constantly whacks hornets' nests, and there would be threats on her life, attempts to frame her, attempts to co-opt her by giving her a show of her own where she could be tamed. I think it could be a good comic with a bare minimum of Superman showing up.