Promethea 12: A history of humanity
Promethea 12 was something of a watershed moment for the series. Previously, the series had been very well-written, with excellent art, but it was still "just" your standard superheroics. This issue is when we first realized that it was going to be something more.
Basically, the issue is the history of humanity told via the major arcana of the Tarot. It begins with the big bang and the planets forming, stuff like that. Then we get to the earliest lifeforms arising on Earth. In these scans, we're picking up at the point when Homo sapiens comes into existence.
The Scrabble tiles along the page bottom are the letters in "Promethea." On each page, they're re-arranged into a new word or phrase, including the title of the issue, "Metaphore."
Due to the legal page limits, I obviously can't post any more, but this is the best part anyway. After this point, the whole things starts to get oddly Eurocentric for something that's purportedly a history of the human race.