Well, I can see Jo having problems with this initially. (Sorry for not posting, by the way. The cell phone broke, and exams were evil >_<)
But the only reason why Jo would have a problem is because she sees it as God's way of saying 'no you can't have Dean' or that she's going to loose him for good. Does that make sense? She's not about to shoot him or anything, but she's definitely going to draw back a little.
That's just me though. I have no idea where to run with this. Not yet. I just got out of class >_<. I'll add more later.