The Framework was created by a scientist with the apparent design to let his girlfriend live on even after she died. I'm not sure on those specifics. It was more or less taken over by the LMD he had created when it was given access to the Darkhold.
So when those in my team were taken and placed into this alternate universe, their biggest regret was changed - a child saved instead of killed, being a teacher instead of a SHIELD agent, things like that. Those changes had a butterfly effect, built upon one another and it ends up with this version of Hydra in control, Inhumans hunted, SHIELD as an underground resistance.... it's bloody hell.