Adding as a suggestion maybe allowing players the option to reboot and start fresh or maybe letting some retain memories for those who might have some connections or interactions they’d prefer not to lose. If you didn’t want everyone to remember Cardiff, you could cap at X characters for each player or x% of each players roster.
I know you are learning to a space theme, so we could just toss our crew into some kind of war or epic conflict that they just get caught in the middle of. Maybe the accidentally piss off some alien race that now wants to make their lives hell? Something a la John’s arrival and accident with Crais’ brother but just maybe on a larger scale.
Or even something as simple as a group of people who does not like these random displaced people showing up and wants to get rid of them, collects a following and comes at them lol, but I think having them caught in the middle of an already ongoing conflict (the Peacekeeper/Scarran Wars but not IDK) could be interesting. Like do they pick a side? Which one? Or do they try to stay out of it but keep getting pulled in???
If you made some stuff puncturable maybe these warring races or factions or whatever get ahold of some source materials and come after them for help (willing or not!) after finding out what they can do?