Its entirely possible. She came to the states somewhere between 1890 and 1915 (I only definitively decided it was pre-WWI). She's stayed mostly in the north east (except where she's worked for a Division) so it really would be reasonable that they'd have come across each other. Especially since she didn't 'retire' until the late 60s in so far as being a 'true vampire' for lack of a better term.
She accepts all flirting while still secretly hating the internet because it ruined her career.