One: Character A has been going blind for about four years, diagnosed with retinitis pigmentosa he’d had time to prepare. He learned how to play piano with his eyes closed and compose by dotting braille paper. He counted the steps to all the places he liked to go and knew his way around the family home just as well with his eyes open or closed. He was glad he came from a rich family, that his New York City brownstone was manageable, that there was staff to make his meals and tell him if his clothes matched. Character B was his real windfall though, Character B was hired by Character A’s family to help tutor him, reading him books aloud, and getting his clothes ready, and the two became fast friends till Character A heard about witchcraft, and Character B wasn't so keen on the idea, saying he didn't want the other to be disappointed...or maybe he was just afraid that if Character A could see, if he could see, that he wouldn’t need him anymore.
Two: Character A is a Roma gypsy. He is a tarot card reader who is good at what he does. He's also a pickpocket, a liar, and a thief of carrying degrees, and travels with a carnival from town to town. Character B is a vampire/demon/witch something of the sort who was hunting in the town Character A was doing cards in, he ran into the young gypsy one day and when Character B caught Character A stealing from him, he gave it back, offered a card reading in return. Character B took him up on it and thought nothing of it, till a warning he got from the gypsy turned out to be true and saved his life, and he's been looking for Character A ever since, maybe to thank him, maybe to kidnap him, maybe just to get another reading.
Also play within the Sherlock, Doctor Who, and Star Trek: Into Darkness fandoms