We3 actually lost me in the first issue and never really improved. There were so many other chilling/heart-wrenching ways that Morrison could have run with the animal experimentation bits, but, IMHO, he went with some pretty lazy tropes worthy of PETA, including Teh Ebil Pet-Snatching Science-Sadists!
That series did finally get me to understand how Frank Quietly has fans, though. He hit it out of the park with the layouts and composition, and there were few enough humans that I wasn't bothered by the usual fug.