Humour comics just need to excersise better judgement when choosing their storylines.
That's kind of what I meant when I complained about overarching storylines. Trying to infuse a humor strip with melodrame (which inevitably happens with a strip that's cast-oriented) will become irritating at best and offensive at the worst (see the great CAD Debacle).
Additionally, Shortpacked!'s main source of humour has always been making fun of Batman, Transformers and their respective obsessive fans. Personally, I've never given a damn about any members of the cast, even way back when they where still trying to be funny. The One Off mocking strips are always way better.