It would have to be either something to do with genitalia (like, maybe she had too much, or the "wrong kind," or that she had a tail as a baby. You never live tail-baby down.
Anyway, this. Was. AWESOME!!! Out of nowhere assassination, ridiculous means to perform it (he could have gone to Gavin's home, or something, but no. Lures him to a total stranger's house to kill him), ridiculous job ($500? He's either desperate or noble. Or both), ridiculous EVERYTHING. But Deadpool is completely professional. Y'know. Other than eating the pizza first. And not cleaning up. And robbing the home owner. But other than that. Completely. Professional.