From an interview with Daniel Way, current writer of Deadpool
Will we see Wade's reaction to the death of his beloved Bea Arthur? I don't suppose even Yelena Belova (Black Widow II) can take her place…
Yes. In an upcoming issue, Deadpool will have a taco-induced hallucination, imagining himself to be in Heaven. He’ll meet Bea, and thank her for being a friend. Together, they’ll travel down a road and back again. He’ll tell her that her heart was true, and that he considers her a pal and a confidant.