The problem with anime (and comics, for that matter), is that there's so much to choose from. Whatever your tastes, you'll find something, hell, quite a few somethings that will grab you.
I took a break from comics, some years back. Then I read a review of Y: the Last Man and it sounded interesting. I picked up the first trade, and within months I was collecting four series in trades, and three in pamphlet form. So much for my break. ;)