They actually do look Asian to the target audience, because to them Asian is the "default" race.
And, y'know, a lot of Asians do have big eyes and pale skin. The unusual hair and eye colors are added for the sake of variety, but even in Japan, various shades of brown hair is common.
When a character in anime is specifically supposed to be Caucasian, they're often pretty obviously marked as such, with traits ranging from a big nose and square jaw to just blond hair and blue eyes.