I'm not seeing some of the criticism made here. People are taking this seriously when, whilst not a comedy IMHO, it's NOT serious, it's a deliberate grotesquerie.
This was essentially made as the Anti-"Marvels", Busiek's marvellous story of a photographer somehow always being in the right place at the right time to experience a breathtakingly large number of significant MU events first hand.
Yes, the story lacks narrative cohesion, but I don't think that's the point. Instead of being awed and impressed by the wonders of the MU, in this universe, a more depressingly real-world situation where being bitten by a radioactive spider will most likely poison you, and passing your atoms through solid matter is dangerous...
As for whether I, as a Brit, find it funny... no for the most part. A certain grim black humour throughout (and the image of a deranged Xavier waving his dick at the x-men shouting "You came from this", is faintly amusing to me for some warped reason)