As nice as it is to finally see Ben in a Spidey comic again, I'm really not feeling this story. Maybe it's just me, but I feel like if you're going to reintroduce Ben, then you need to - well - make the story about Ben instead of the crazy dude who thinks Ben killed his family.
It was nice to see Ben in the lab, though! I always liked seeing Ben doing that kind of work (I noticed he even worked as a science teacher once, years before Pete).
Oh, and I'm calling it right now. Either Kaine did the deed or Ryder killed his family and, having gone crazy with grief or something, has deluded himself into thinking Ben's the guilty one.