Rowena, Ruby, Meg, Bela Talbot, Charlie Bradbury, Jo or Ellen Harvelle, Mary Winchester, Anna Milton... or another women from the series for Dean Winchester?
May be up for some rough and tumble times in a crossover scenario too depending on the woman. Stranger Things, Buffy the Vampire Slayer, True Blood, Dexter, The Good Place... just to name a few that I can immediately think of ideas for.