My top picks would include George Takei as the Sophia; Sigourney Weaver as the Blanche; Jasmine Guy as the Dorothy. But there are so many wonderful faces. Ted Danson, Helen Mirren, Ming-Na Wen, John Stamos, Patrick Stewart, Sam L. Jackson, Tom Hanks, Vanessa Williams, Meryl Streep. The list goes on!
And oh no, I almost pressed enter before submitting the actual joy that is Betty White for your consideration.