Hunter'd be easy for me to pull off, even with all the other places I'm in (if you guys would even want one). And if I got Hunter, I'm sure I could talk my best friend into picking up Blake. I would pick up Zhane, but I haven't watched Space in ages, so I'm sure I'd be rusty.
As for villains, would having a major character be allowed in the same instance? The only real villain I grew attached to was either Zedd/Rita or Lothor.