In 2008, the picturesque state of Washington was turned upside-down when a nuclear reactor suddenly began to overheat and meltdown. All neighboring residences were immediately evacuated while official began the cleanup. Unfortunately, in the process of re-stabilizing the power plant, it became clear that unknown levels of radiation had been leaking into the atmosphere for several months, if not longer, before the plant was deemed to be a danger. Anyone living within a 100 mile radius was strongly encouraged to seek medical attention to screen for resulting medical problems. The response was overwhelming and the hundreds of people believed to be affected were offered a refuge on an island off the coast, Destruction Island. Here, a typical suburban town was established in place of the former wildlife preserve, in the hopes of offering some sense of normalcy. The cornerstone of Destruction is a special facility, where 'victims' of the radiation contamination receive treatment and training to assist in adjusting to their new lives. However, all is not well on the Island. Throughout the community, tensions run rampant, and without the presence of an official police force, vigilante justice keeps society in order.

Destruction Island is a modern-day, genetic-mutation based SL set on a real-life island off the coast of Washington state. All characters are human, with or without genetic mutation. Each character may choose a mutation must pick one power from the list. Over the course of game play, additional associated powers may develop. Also, if the player so chooses, their character may be entered into a mod-controlled lottery to pick initial abilities, secondary abilities, or "regular" human identity. All types of characters are encouraged, both human and super powered. All occupations and roles are welcome and connections with existing characters are encouraged. Multiple opportunities for play will be available each month, both for group and individual interaction, with characters who know each other and with strangers.