Jake/Judas: It'd be distant friends... more like acquaintances that chat. He could help her with her classes. Jake is a bit hard pressed to befriend females or anyone for that matter. But that doesn't stop the interaction from being like a friendship.
Sean/Horus: And he'll jokingly do the same back at her. He'd push for a friendly argument over the pronunciations of words. He does that. And he's a Major flirt.
Melody/Melpomene: Does she have a dark sense of humour? Because they could be as close to besties as Mel gets if she did. They can watch thrillers/horror movies together.