"I don't know who to believe anymore. Everyone before wasn't an issue, but now everyone could be a killer. I can't sleep, I don't feel like eating, my days and nights run together and I'm lost, you know? Lost. All I've got is you and you're the reason I'm here in the first place." He's not referring to his loss of powers, he's referring to who Charles is to the world. Without Charles there'd be no Wesley. Without mutants there'd be no war, nothing to tear them apart.