Karev, you are the best bro in the world okay. I'm kind of leaning towards there being no meds and also maybe not a set diagnosis. He could've glitched himself just as well so have fun with that frustration I guess? Let's find out if people can die in the game and also die in real life.
I agree that it'd make sense for them to drift apart a bit, maybe scrap the romantic part of their relationship and have an amicable breakup with frequent dog children visits. Thinking about it, Aidan would probably have a rough time being in a relationship with no changes in their future in the way of children so as hard as he'd try, it may be on him that it doesn't last forever.
Spike totally will. I don't know about Wade but Spike totally will help his hopeless girl next door. It may be the project that keeps him from getting totally fed up with prison.