LOL it should! By now it would be fairly clear Ryu is geeky - he's mentioned anime and manga etc a few times so feel free for Lei to have taken note! Oh, and if he's friends with Audrey then he would know all about Audrey dating Ryu, and then Ryu 'dumping' her for Willow when he was under the influence of the love potion, so... Lei might be a bit annoyed with him?
I should note that Duck will talk to ANYone if he feels the urge so he likely has talked to Lei and given him baked goodies in the past.
I like the idea of Georgie and Lei being friends! She tends to fall into the friend catagory, heh, but she loves all her friends and would enjoy coaxing Lei out to have some fun.
Agree re Edwin and Lei, so we'll see what develops in game!