Six Feet Under
Brenda: I think it's all just totally random. Nate: Really? Brenda: Yeah. We Live, we die, ultimately nothing means anything. Nate: How can you live like that? Brenda: I don't know. Sometimes I wake up so fucking empty I wish I'd never been born, but what choice do I have?
(yes, it's old, but i've just been watching it lately)