Back just after Civil War Stark sprang a power nullifier trap on the New Avengers after luring them in with a fake of Captain America's body. It neutralized most of them, but didn't seem to have any effect on Dr. Strange (much to the consternation of everyone on the opposing team, who got their asses handed to them as a consequence). So I think there are still limits to how macguffin-y the technology can be.