It makes sense, but it's more than a bit trite, especially since I sincerely doubt that May and Jay will be allowed to get married - that would, after all, put Uncle Ben's influence on the title that much further in the past, and NuSpidey cannot allow Peter to move past the deaths of either Uncle Ben or Gwen Stacy - so I suspect we might see Otto storming in to the wedding, causing a scene as he objects, and inadvertently killing Jay in the middle of an Otto/Spidey fight, which would a) give Peter more of a reason to feel guilty and b) give Jonah yet another reason to hate Spider-Man.