Just a sample from one of the few online comics that are not anti-drug. I wouldn't call Mr. Yungbluth an advocate exactly, but he's admitted to using pot himself and seems to be pro-choice when it comes to controlled substances.
Beepo (the clown) is an alcoholic, Roadkill (the cat) is a drug addict. It's not online anymore, but there was a story called "Best Buds" where Beepo leaves to buy pot while Roadkill goes through withdrawals from heroin (collected in the trade "THE GREAT TASTE OF DEEP FRIED", which I own a copy of).
Also check out this flash cartoon of the Deep Fried duo getting high with a bong. While you're there, feel free to browse around the site and check out the WEAPON BROWN series, which is my most favoritist post-apocalyptic peanuts parody.