I'm an asshole. I'm pretty sure I'm also going to officially be your stepdad, so I'm supposed to ruin your life.
Can't really blame you on those. Simmons is one of those people who's sweet, so you don't really want to equate her with sex, but you don't want to murder her because she's basically a basket of kittens. Skye is feisty and hot, so sex would be fun. And May would be the most challenging to kill, and therefore the most rewarding.