Really some of the humor is rather lost on me, because their fandoms aren't mine. As well as some I wouldn't get without reading the description at the bottom. Maybe it's just me, but I think comic commentary should be an accent, not the punchline, so to speak. The Ragdoll one(08/08/07) for instance, wouldn't been MUCH clearer if you just added and off-screen "flush" sound effect in the first panel.
Anyway, that was just my impression, anyway. You don't really have to follow my advice, but good luck either way. :)