She had, of course, seen Dogma in her days as a mortal, so the reference was not lost on her. She flashed him a somewhat annoyed look at the statement. "As funny as that movie was, you wouldn't want to meet the Metatron." no, if chose to make an appearance then things were bad, and they were probably dead. She wasn't sure there was a connection to Angles dying and orders that seemed off. There had to be.
"Who would want to? Is that an another tempt at a joke? Every demon in hell would want to. Many people would want to." they weren't always very good at swaying people to their side. "But who could is much more limited. I know what you're thinking. Lilith can't kill an Angel, at least not on her own." she would need some sort of weapon, and she was quite sure Lilith didn't have any.
When a nurse poked her head in, she looked at Anna and told her she had ten minutes left. And simply smiled and nodded, before turning back to Dean. "The point is, Dean. I don't believe God is in Heaven. He left, now His Angles are running the show and they're view on things is...much different."