Sam didn't like where this was going. He wanted to tell Dean to make a run for it - for them both to, in fact - but it wouldn't have mattered in the long run. Sam was not stupid enough to believe that Uriel, an angel, could have been outrun without a bit of help from someone powerful enough to get them both away and hidden faster than he could. Fact of the matter was, Sam didn't know anyone who could do anything like that. Hidden? Yes, Ruby could manage the hex bags for them. But zapping them away in a blink of an eye? No, they were pretty screwed in that aspect. Maybe some of the Harry Potter folk back at the apartment could have done as much, but there was no way Sam was going to be able to contact them, get in touch with Ruby, and follow through on distracting Uriel long enough to keep him from hauling Dean off to God only knew where.
"He's not going with you," Sam added, stepping in closer. This wasn't the first time that Sam had challenged Uriel's authority. Of course, before Uriel had threatened to turn him into a pile of dust, so doing so was clearly an unintelligent move on his part. Yet, he was a Winchester. And if there was anything notable about his bloodline, it was that they were all stubborn assholes.
Uriel, still, ignored Sam. He smirked at Dean all the same. "He will always be your business, Dean Winchester. You are, after all, chosen." The sound of wings swishing through the air quickly followed the statement, Uriel vanishing and reappearing just behind Dean in the blink of an eye. He placed a hand on Dean's shoulder, gripping it tightly. "Besides, who here said you had a choice?" Before Dean could wriggle free, Uriel finally acknowledged Sam with a smug smirk and yanked Dean backward, pulling him through the air with him. Seconds later, they were standing in a rather plain, dark room. There was a table surrounded by chairs mounted ahead of them, currently occupied by another of Uriel's siblings.
Meanwhile, back at the motel several states away, Sam had lost it. He grabbed onto the nearest chair and hurled it across the room, swearing all that he had once prayed to straight to Hell in all his rage.