Most of us ended up in Seattle after Manticore burned down. It was the closest city to the compound, and getting out of Seattle's harder and more expensive than it should be.
They used transgenic techniques to artificially introduce foreign DNA into human embryos. It's also completely unethical and very expensive.
Well, back home it's just Max and Joshua. Logan and Cindy probably don't count, since they're convinced I'm a happy go-lucky psychopath. (I'm not.)