Blossom, Teddy & Peter
"Billy is my best friend!" Okay, so, the weirdness aside, Blossom could work with this. Peter was a superhero like her, and Billy said that Teddy was super amazing awesome powerful, so this would be fine!
"You're the Teddy then?" Later, she was sure they'd do the 'lol, I'm dating your friend' thing and that'd be fine, she'd laugh and give the joking 'hurt him and I'll bury you' thing, but for right now... well, weird world.
"Hey, at least we're the super power team, right? Whatever this insanity is, we can handle it." Except, well, "Can we handle it? You think someone needs to get married? Or are we stopping a wedding? Man, I'm still only half convinced I know which Tim Burton world this is."