Staying Rez - Rez is married to Riley and living with him and the rest of the clan in the house off campus. Not only does he own a local business, an indoor family fun center with a skate park where he gives lessons, he also works at TJS teaching inner beast control to the high school age and younger students.
Nico - Nico is married to Lyle and living on campus. Not only do they have a very lucrative marijuana business, he teaches advanced hydroponics as part of a career certification curriculum.
Charlie - Charlie is still married to Trevor and living with Riley and Rez in their family home where they are raising their collective brood. She's a werelion now, thanks to her darling hubby. And it has taken her some time, because she had to get her high school diploma first and work toward getting her rights back from the court by proving her competency, etc, but she eventually earned her degree in social work and is working at TJS as a counselor for students who need help integrating into the student body and resolving issues in their home lives, etc.
Leaving Cissy - She is off all crazy happy and married to Tiger in the wild blue yonder somewhere.
Syntax - Gone. Not sure where or what he's doing, but he's not there.
Estrella - Off in DC working for changes in society that will help girls who are growing up in situations similar to her own.
Ingrid - She's actually settled down and working the shop where Nico and Lyle sell their wares in Boston. She may be about as an NPC from time to time.
Devon - He and Blue had to take off somewhere because it became obvious that neither of them were aging. Rumor has it that they were both involved in modeling now.
Alex - Since Lloyd is sticking around, I have to assume that he and Alex split up at some point and Alex went off on his own somewhere to open a new practice, etc.
James - He's not a currently played character, but he wants me to mention that he is in politics now and is probably the mayor or governor of something. XD
New EJ Reznick - This is Rez and River's son. He is a were-hyena, like his father. His name is Ethan Jonathan Reznick, but he prefers to be called EJ. He would be around 16 now. I will be getting him written up shortly.
Undecided Hope - I know she's been gone for most of the last 10 years, deciding that she needed to go and do work to bring about some good instead of hanging around TJS fixating on her crazy love life. She's since made a lot of findings and developed quite a few things to benefit supernaturals. She still owns TJS, but she doesn't run it. She may return at some point in the game.