Wooden stake to the heart and beheading in most cases. If they're my kind of vamps, they have a mutated 'game face' when the fangs show. Crucifixes, holy water, and don't invite them in to private residences. Soulless killers too, so don't need to feel guilt when you stake them. Literally soulless mind you. Fire and sunlight are always great too. They've got advantages in strength and speed though, so if you don't think you can take them, probably better to avoid them if you can.