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Metamorphmagi are very rare in my world, and we never chose to be what we are. So no, we're not treated with as much suspicion as you think.
As for the users of Polyjuice Potion, that's where people start getting suspicious. Polyjuice Potion can only aid you in mimicking someone else's appearance and I hear it tastes awful. There's also the gross part where you have to put someone's DNA in the potion for it to work. Your choices are essentially hair or nail clippings.