For Sam, I've got Clint, he's been around since mostly the start of the game, so developments, but I would love to talk about potential interactions from when they were on the run before Clint took the deal.
I also have 616 Carol, who is friendly with 616 Sam but didn't have a lot to do with Ultimates Sam who was in the game, so it'd be a fresh line, and she's pretty easy going (she's pre-Civil War 2 if you know the comics).
Other Marvels are Ellie who is from Deadpool, Pyro who is from the first X-Men boot-up and Quill, who knows of Sam in a peripheral way but is down to clown.