One of my idle fanboy ideas for a Superman sequel was Brainiac kidnapping Lucy Lane to use as a weapon against Superman. He'd alter her with Kryptonian DNA he had from Kandor (full of dead Kryptonians) into a hybrid he names XTC. In her "super" form she'd look like XTC/Brainiac's Daughter from KINGDOM COME. Superman would fight a foe with most of his powers (but not at his levels) that he can't really hurt as it's Lois' sister.
Lucy Lane getting "super" powers for nefarious ends must be a common fanboy idea. I'm not crazy about General Lane being nutty, though.