If you can put together an actual comic book, writing and art packaged together in a done deal, Image still takes that kind of submission. I've heard that Marvel, on the other hand, are royal dicks.
As far as the quality of the submission, I dig it but not for Felicia.
You have a kind of Venture Bros. with a touch of Strangers in Paradise thing that'd work really well for down to Earth characters. I'd recommend something like Runaways, but that's just me.