Seriously Pym, it doesn't do to understimate, oh, Richards, or Spider-man, or Tony Stark. You wouldn't be too off if you decided to let Norman plot away in some dirty dank corner somewhere besides the Hudson. I mean, what's the worse that can happen? Another elaborately constructed plot displaying Norman's knowledge of Parker's secret identity, with probably a reference to Gwen Stacy, a moment of madness, before being punked by a pissed off Spider-man.
Let's face it - Spider-man is damn impressive and has a history of hitting above his powerclass on a regular basis, but he's not exactly Doctor Strange, Reed Richards, or Captain fuckin' America. Osborn wouldn't have the faintest clue as to how to take down any of them. Maniacal corporate losers dressed in green and purple togs are the least of their worries.