Agree entirely. It is in fact that "such a waste" line that kills me, because it is a small insight to how he rationalize being a supervillain (and showing that is what makes villains like Doom and Magneto so great, IMO). Most people he terrorizes probably beg for their life, or cower, and he would not give a second thought to killing them, but here is someone he feels the world actually deserves to have, a strong, intelligent women willing to stand up for her principles no matter the cost.
There's another reason I think this scene is powerful, besides the odd juxtaposition of quotes, old english, and superheros. It really stands on it's own. You don't need to know what's going on or what the world-shattering stakes are to know how serious this is for the both of them.