Generally Mass Effect is actually one of the few games (besides like Skyrim, which I have a personal headcanon about Margo attempting because she fucking loves Game of Thrones and being so desperately bored by it she swore to never play another open world game ever again) Margo knows about, because men bitched about it so obviously she wanted to see why it was so amazing. Because that's who she is. I don't think she'll recognize much more than Sara though - just cause games don't catch her eye as much obviously~
I haven't played Dark Souls in agggeeeeeesssssssss. So I'll look back over Solaire to refresh myself~