I guess going for the eye might be a good last resort, it should still cause severe pain that will hopefully make them back off even if it doesn't kill them.
If it's for my own survival, the means don't bother me much, so I would be fine with that part, but I have already asked Edge for a mission for some other items. I don't think deadly poison is completely necessary though, just something to slow whoever down enough before they bleed to death.