Yes. Yes a lot would happen, because let's be honest here. There was six boys growing up. Five... five of them now. And between all of those siblings someone has called someone such a thing at least once in the last seventeen years.
Even with the smile, and even with Ron having the emotional understanding of a teaspoon it wasn't too difficult to see the truth behind the letters. "Yeah well. Life can catch you up to if you try that."
He sighed for a moment, awkwardly sighing. "You should get a hobby. Maybe not Quidditch, but something to wake you up in the morning."